Avonex(interferon beta-1a)
Avonex, Rebif (interferon beta-1a) is a protein pharmaceutical. Interferon beta-1a was first approved as Avonex on 1996-05-17. It is used to treat multiple sclerosis in the USA. It has been approved in Europe to treat multiple sclerosis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Avonex, Rebif (discontinued: Avonex)
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Interferon beta-1a
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Avonex | interferon beta-1a | Biogen | N-103628 RX | 2003-05-28 | 2 products |
| Rebif | interferon beta-1a | EMD Serono | N-103780 RX | 2002-03-07 | 6 products |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| avonex | Biologic Licensing Application | 2016-03-31 |
| avonex avonex avonex pen | Biologic Licensing Application | 2020-12-16 |
| avonex avonex pen | Biologic Licensing Application | 2024-11-13 |
| rebif | Biologic Licensing Application | 2010-01-14 |
| rebif rebif rebidose | Biologic Licensing Application | 2025-09-22 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| multiple sclerosis | EFO_0003885 | D009103 | G35 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
interferon beta-1a, Avonex, Biogen Inc. | |||
| 2103-05-17 | Orphan excl. | ||
Patent Expiration
No data
Clinical
Clinical Trials
247 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | 5 | 2 | 7 | 15 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | 1 | — | 4 | 4 | 2 | 11 |
| Sclerosis | D012598 | — | — | — | — | 1 | 1 | 2 | 4 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crohn disease | D003424 | EFO_0000384 | K50 | — | 1 | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Interferon beta-1a |
| INN | — |
| Description | Interferon beta precursor (IFN-beta) (Fibroblast interferon) |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201562 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00060 |
| UNII ID | — |
Target
No data
Variants
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Financial
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Avonex – Biogen
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,106 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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216,682 adverse events reported
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